Headwaters to Oceans (H2O) is a 2-day conference to promote integration across disciplines, sectors, organizations, and institutions around common interests related to water, oceans, coastal environments, resilience, and terrestrial interfaces with marine systems. Through dynamic panels, presentations, and working groups attendees will identify new challenges and advance solutions-oriented thinking about these topical areas. The conference will highlight impactful projects and scholarship, and translate science for policy and action. In addition to creating opportunities to share best practices, H2O will engage and provide networking opportunities to a diverse cross-section of leaders and knowledge-brokers, including those traditionally underrepresented in these conversations.